ea0032p77 | Bone and Osteoporosis | ECE2013
Goia-Socol Monica
, Duncea Ileana
, Goia-Socol Mihai-Andrei
, Hazi Georgeta
, Leucuta Daniel-Corneliu
, Tomoaie Gheorghe
, Suteu Mihai
, Georgescu Carmen Emanuela
One of the causes of secondary osteoporosis is type 1 DM (1DM), an autoimmune disease where insulin replacement is mandatory for controlling blood sugar levels. Among the mechanisms involved in osteoporosis in 1DM is increased bone resorption, mainly osteoclasts being responsible for this process. However, osteoblasts also seem to have an active contribution by secreting products with resorptive properties, one of these being cysteine protease Cathepsin K, as mentioned by a fe...